Description

2,4,5-Tris[(Trimethylsilyl)Oxy]Pyrimidine is a highly functionalized pyrimidine derivative featuring three trimethylsilyloxy protecting groups. This compound is a valuable synthetic intermediate and protecting group reagent, prized for its ability to enhance solubility and stability in organic synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex nucleoside analogs and heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer drug discovery.
• Protecting Group Reagent: Used to protect hydroxyl groups on pyrimidine scaffolds during multi-step synthetic sequences, facilitating selective reactions.
• Agrochemical Research: Intermediate in the development of new herbicides and fungicides based on modified pyrimidine structures.
• Material Science Precursor: Serves as a starting material for creating functionalized organic molecules used in advanced materials.
• Academic & R&D Laboratories: Employed in methodological studies and the exploration of new synthetic pathways in heterocyclic chemistry.

Basic Information

Product Name	2,4,5-Tris[(Trimethylsilyl)Oxy]Pyrimidine
CAS No.	32865-92-2
Molecular Formula	C13H28N2O3Si3
Molecular Weight	356.63 g/mol
Synonyms	Pyrimidine, 2,4,5-tris[(trimethylsilyl)oxy]-; 2,4,5-Tris(trimethylsiloxy)pyrimidine; 2,4,5-Tris-O-(trimethylsilyl)pyrimidine; TMS-protected pyrimidinetriol; 2,4,5-Trihydroxypyrimidine tris(trimethylsilyl) ether; NSC 163063; 32865-92-2
EINECS	Contact for details

Quality Control

Our 2,4,5-Tris[(Trimethylsilyl)Oxy]Pyrimidine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.