Description

2-Chloro-5-Iodopyrimidine is a versatile halogenated pyrimidine building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chlorine and iodine substituents, makes it a critical intermediate for constructing complex molecules through selective cross-coupling and nucleophilic substitution reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs), nucleoside analogs, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, including antiviral and anticancer agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides.
• Material Science: Serves as a building block for creating functionalized organic materials and ligands for catalysis.
• Cross-Coupling Reactions: The iodine moiety is highly reactive in palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) for carbon-carbon bond formation.
• Nucleoside Chemistry: Integral for modifying pyrimidine bases to create analogs for biochemical research.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies in academic and industrial R&D labs.

Basic Information

Product Name	2-Chloro-5-Iodopyrimidine
CAS No.	32779-38-7
Molecular Formula	C4H2ClIN2
Molecular Weight	240.43 g/mol
Synonyms	5-Iodo-2-chloropyrimidine; 2-Chloro-5-iodo-pyrimidine; Pyrimidine, 2-chloro-5-iodo-; 2-Chlor-5-jodpyrimidin; 2-Chloro-5-iodopyrimidine (32779-38-7)
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Iodopyrimidine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong acids and bases. The compound is light-sensitive (store away from light) and should be handled in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.