Description

Colistin Nonapeptide is a cyclic peptide derivative of the polymyxin antibiotic colistin, known for its potent membrane-disrupting properties. This compound serves as a critical intermediate and research tool for studying bacterial resistance mechanisms and developing novel antimicrobial agents. It is essential for pharmaceutical R&D, academic research, and the development of diagnostic assays targeting Gram-negative pathogens.

Application

• Antimicrobial Research & Development: A key intermediate in the synthesis and structure-activity relationship (SAR) studies of polymyxin antibiotics.
• Mechanistic Studies: Used to investigate bacterial outer membrane permeabilization and the mechanisms of colistin resistance.
• Diagnostic Reagent Component: Employed in the development of sensitive assays for detecting bacterial endotoxins and specific pathogens.
• Pharmaceutical Intermediate: Serves as a building block in the production of specialized antimicrobial peptides and conjugates.
• Biochemical Tool: Utilized in microbiology and biochemistry laboratories to study cell membrane interactions and lysis.

Basic Information

Product Name	Colistin Nonapeptide
CAS No.	32530-94-2
Molecular Formula	C₄₈H₈₅N₁₃O₁₃
Molecular Weight	1044.3 g/mol
Synonyms	Polymyxin E Nonapeptide; Colistin Nonapeptide Methanesulfonate (common salt form); N-Acetylcolistin Nonapeptide; Cyclo[Thr-Dab-Dab-Dab-Dab-Dab-Dab-Leu-Dab] (cyclic structure); Colistin Ring Fragment; Antibiotic 69-21-8 fragment; Polymyxin E1/E2 Nonapeptide
EINECS	Contact for details

Quality Control

Our Colistin Nonapeptide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Single Impurity (HPLC)	≤2.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.