Description

Sisomicin is a potent aminoglycoside antibiotic derived from *Micromonospora inyoensis*. It is valued for its broad-spectrum bactericidal activity, particularly against Gram-negative bacteria, including many strains resistant to other antibiotics. This makes it a critical component in pharmaceutical research and development for novel antimicrobial agents. Key industries requiring this compound include pharmaceutical manufacturing, academic and industrial microbiology research, and veterinary medicine.

Application

• Pharmaceutical Intermediate: Serves as a key starting material or reference standard in the synthesis of advanced antibiotic formulations and novel drug candidates.
• Microbiological Research: Used as a selective agent in culture media and in studies investigating bacterial resistance mechanisms and aminoglycoside pharmacology.
• Reference Standard: Employed in analytical laboratories for quality control (QC) and quality assurance (QA) testing, including HPLC and microbiological assay calibration.
• Veterinary Medicine: Investigated for use in developing treatments for bacterial infections in livestock and companion animals.
• Biochemical Studies: Utilized in research exploring protein synthesis inhibition and the interaction of aminoglycosides with bacterial ribosomes.

Basic Information

Product Name	Sisomicin
CAS No.	32385-11-8
Molecular Formula	C19H37N5O7
Molecular Weight	447.53 g/mol
Synonyms	Sisomicin; Antibiotic 6640; Sisomicin sulfate (salt); Rickamicin; Ensamycin; 5-Dehydro-2-deoxy-4-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-6-O-(3-deoxy-4-C-methyl-3-methylamino-β-L-arabinopyranosyl)-1-N-ethyl-1,3-dideoxy-D-streptamine; (2S,3R,4S,5S,6R)-4-Amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,4R,5R)-3,5-diamino-4-ethyl-2-{[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]oxy}oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol
EINECS	251-011-1

Quality Control

Our Sisomicin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), purity assay, and impurity profiling to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 1.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.