Description

3-Oxo-3,4-Dihydro-2H-1,4-Benzoxazine-6-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative used as a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile electrophilic reagent for introducing the sulfonamide moiety, enabling the development of novel compounds with targeted biological activity. This intermediate is essential for research and production in the pharmaceutical and agrochemical industries, particularly for medicinal chemists developing new active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting neurological and inflammatory pathways.
• Agrochemical Synthesis: Used to create advanced sulfonamide-based herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Chemical Biology Probes: Employed in the design of activity-based probes and molecular tags for proteomics and enzyme studies.
• Dye and Pigment Manufacturing: Intermediate for synthesizing specialized sulfonated colorants and optical brighteners.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules for client R&D programs.

Basic Information

Product Name	3-Oxo-3,4-Dihydro-2H-1,4-Benzoxazine-6-Sulfonyl Chloride
CAS No.	31794-45-3
Molecular Formula	C8H6ClNO4S
Molecular Weight	247.66 g/mol
Synonyms	1,4-Benzoxazine-6-sulfonyl chloride, 3,4-dihydro-3-oxo-; 3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-sulfonyl chloride; 2H-1,4-Benzoxazine-6-sulfonyl chloride, 3,4-dihydro-3-oxo-; 3,4-Dihydro-3-oxo-2H-1,4-benzoxazine-6-sulfonyl chloride; 6-(Chlorosulfonyl)-3,4-dihydro-3-oxo-2H-1,4-benzoxazine
EINECS	Contact for details

Quality Control

Our 3-Oxo-3,4-Dihydro-2H-1,4-Benzoxazine-6-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.