Description

Boc-His(Boc)-Oh Dcha is a protected derivative of the amino acid histidine, widely utilized as a key building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates to ensure the fidelity and yield of complex peptide sequences. It is primarily used in pharmaceutical R&D and production for the development of therapeutic peptides, as well as in biochemical research for studying protein structure and function.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the controlled, sequential addition of histidine residues while protecting reactive side chains.
• Pharmaceutical Intermediates: Serves as a key raw material in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation and Labeling: Used in the preparation of modified peptides for diagnostic assays, imaging probes, and targeted drug delivery systems.
• Biochemical Research: Employed in academic and industrial laboratories for studying histidine's role in enzyme catalysis and metal binding.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive peptides.

Basic Information

Product Name	Boc-His(Boc)-Oh Dcha
CAS No.	31687-58-8
Molecular Formula	C22H38N4O6
Molecular Weight	454.56 g/mol
Synonyms	N-α-Boc-N-π-Boc-L-histidine; Boc-L-histidine(Boc)-OH; Nα-Boc-Nim-Boc-L-histidine; tert-Butyl N-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(1H-imidazol-4-yl)-1-oxoprop-2-yl]carbamate; Boc-His(Boc)-OH; N-Boc-N'-Boc-L-histidine; (S)-2-((tert-Butoxycarbonyl)amino)-3-(1-(tert-butoxycarbonyl)-1H-imidazol-4-yl)propanoic acid; L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-N-[1H-imidazol-4-yl)methyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our Boc-His(Boc)-Oh Dcha is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific research or cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.