Description

,-Diacetyldigoxin CAS NO 31668-45-8 is a chemically modified derivative of the cardiac glycoside digoxin, characterized by the acetylation of its sugar moieties. This modification is crucial in pharmaceutical research for studying structure-activity relationships and developing prodrug strategies to optimize the pharmacokinetic profile of digoxin-related compounds. It serves as a key intermediate and reference standard for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on cardiovascular drug development and analytical method validation.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthetic pathway for novel cardiac glycoside derivatives and prodrugs.
• Biochemical Research: Used as a tool compound to investigate the metabolism, transport, and mechanism of action of digoxin analogs.
• Reference Standard: Employed in analytical laboratories for the qualitative and quantitative analysis (e.g., HPLC, LC-MS) of digoxin and its metabolites in various matrices.
• Prodrug Development: Acts as a model compound for designing prodrugs with improved bioavailability or targeted delivery profiles.
• Academic Research: Utilized in university and institutional labs for pharmacological studies related to sodium-potassium ATPase inhibition.
• Quality Control: Functions as an impurity standard or system suitability marker in the quality control of digoxin API and finished dosage forms.

Basic Information

Product Name	,-Diacetyldigoxin
CAS No.	31668-45-8
Molecular Formula	C₄₉H₇₄O₁₆
Molecular Weight	931.1 g/mol
Synonyms	Diacetyldigoxin; 3''-O-Acetyldigoxin; 4''-O-Acetyldigoxin; Digoxin Diacetate; α,β-Diacetyldigoxin; Digoxin 3'',4''-Diacetate; 3'',4''-Di-O-acetyldigoxin; Lanatoside C Aglycone Diacetate
EINECS	Contact for details

Quality Control

Our ,-Diacetyldigoxin is produced and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with a detailed Certificate of Analysis (COA), which includes results from advanced techniques such as HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards expected for pharmaceutical reference materials and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.