Description

3',5'-Di-o-Benzoyl-2,2'-Anhydro-L-Uridine is a key protected nucleoside intermediate, specifically designed for the synthesis of modified oligonucleotides and nucleoside analogs. Its value lies in providing a stable, reactive scaffold for precise chemical modifications, enabling advanced research and development in nucleic acid chemistry. This compound is essential for pharmaceutical researchers, biotech companies, and academic institutions focused on developing novel therapeutics, including antisense oligonucleotides and prodrugs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside prodrugs.
• Oligonucleotide Synthesis: Used in the preparation of modified RNA and DNA strands for therapeutic and diagnostic applications.
• Antisense Drug Development: Serves as a precursor for creating chemically modified nucleotides that enhance the stability and efficacy of antisense oligonucleotides.
• Biochemical Research: A valuable tool for studying nucleic acid structure, function, and enzyme interactions in a controlled manner.
• Prodrug Synthesis: Enables the development of masked nucleoside analogs with improved pharmacokinetic properties.
• Labeled Compound Preparation: Acts as a starting material for synthesizing isotopically or fluorescently labeled nucleosides for tracing and imaging studies.

Basic Information

Product Name	3',5'-Di-o-Benzoyl-2,2'-Anhydro-L-Uridine
CAS No.	31615-96-0
Molecular Formula	C24H20N2O7
Molecular Weight	448.43 g/mol
Synonyms	2,2'-Anhydro-3',5'-di-O-benzoyluridine; 1-(3,5-Di-O-benzoyl-2,2-anhydro-β-D-lyxofuranosyl)uracil; 3',5'-Di-O-benzoyl-2,2'-anhydrouridine; 2,2'-O-Cyclouridine 3',5'-dibenzoate; L-Uridine, 3',5'-di-O-benzoyl-2,2'-anhydro-; 31615-96-0; DBU (protected nucleoside intermediate)
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Benzoyl-2,2'-Anhydro-L-Uridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere or with desiccant to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.