Description

4-Iodopyrimidine is a versatile halogenated heterocyclic building block of significant importance in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and advanced materials. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable, high-purity intermediate for cross-coupling reactions and nucleophilic substitutions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside analogs, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in creating novel fungicides and herbicides with specific modes of action.
• Material Science: Serves as a building block for organic semiconductors, liquid crystals, and functional polymers.
• Cross-Coupling Reactions: An excellent substrate for Suzuki-Miyaura, Stille, and Negishi couplings to introduce the pyrimidine moiety.
• Nucleophilic Substitution: The iodine atom is readily displaced by various nucleophiles, enabling diverse functionalization.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry in drug discovery pipelines.

Basic Information

Product Name	4-Iodopyrimidine
CAS No.	31462-57-4
Molecular Formula	C4H3IN2
Molecular Weight	205.98 g/mol
Synonyms	Pyrimidine, 4-iodo-; 4-Iodo-1,3-diazine; 4-Iodopyrimidine; 4-Iodo-1,3-diazabenzene; 4-Pyrimidinyl iodide; 1,3-Diazine, 4-iodo-
EINECS	Contact for details

Quality Control

Our 4-Iodopyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.