Description

4-Bromopyrimidine is a versatile brominated heterocyclic building block essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, which are fundamental for constructing complex molecular architectures. This high-purity intermediate is critically needed by pharmaceutical, agrochemical, and advanced materials research organizations for the development of active ingredients, ligands, and functional organic compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized pyrimidine-based ligands for transition metal catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLED emitters and charge-transport molecules.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki, Stille, and Negishi couplings to introduce the pyrimidine moiety.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of molecular probes.

Basic Information

Item	Details
Product Name	4-Bromopyrimidine
CAS No.	31462-56-3
Molecular Formula	C4H3BrN2
Molecular Weight	158.98 g/mol
Synonyms	4-Bromopyrimidine; Pyrimidine, 4-bromo-; 4-Bromo-1,3-diazine; NSC 403914; 4-Brom-1,3-diazin (German); 4-ブロモピリミジン (Japanese); 4-溴嘧啶 (Chinese)
EINECS	Contact for details

Quality Control

Our 4-Bromopyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	82 - 86 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.