Description

2-Fluoropyrimidine is a versatile fluorinated heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring a fluorine atom on the pyrimidine ring, makes it a critical intermediate for introducing fluorinated motifs into target molecules, which can significantly alter their physicochemical and biological properties. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, including kinase inhibitors, antiviral agents, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where fluorination enhances stability and efficacy.
• Material Science Research: Serves as a precursor for creating fluorinated organic materials, such as liquid crystals or polymers with tailored electronic properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) for constructing complex biaryl systems.
• Nucleophilic Aromatic Substitution: The fluorine atom is an excellent leaving group, facilitating further functionalization of the pyrimidine core.
• Chemical Biology Probes: Utilized in the synthesis of fluorinated probes and tags for studying biological processes.

Basic Information

Product Name	2-Fluoropyrimidine
CAS No.	31375-35-6
Molecular Formula	C4H3FN2
Molecular Weight	98.08 g/mol
Synonyms	2-Fluoropyrimidine; Fluoropyrimidine; Pyrimidine, 2-fluoro-; 2-Fluoro-1,3-diazine; 2-Fluor-1,3-diazin; 2-Fluoropyrimidin; 31375-35-6
EINECS	Contact for details

Quality Control

Our 2-Fluoropyrimidine is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each shipment, supporting your R&D and production needs with reliable data and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its nature as a fluoride/strong alkali and high volatility, ensure containers are kept tightly sealed and away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.