Description

DL-Histidine Hydrochloride Dihydrate is a high-purity, pharmaceutically relevant amino acid derivative essential for biochemical research and formulation. This compound serves as a critical building block and buffering agent in advanced life science applications, ensuring precise pH control and stability. It is primarily utilized by manufacturers and research institutions in the pharmaceutical, biotechnology, and nutraceutical sectors for developing parenteral nutrition solutions, cell culture media, and diagnostic reagents.

Application

• Pharmaceutical Intermediates: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) and peptides.
• Parenteral Nutrition Formulations: An essential amino acid component in intravenous (IV) nutrition solutions for clinical use.
• Biochemical & Cell Culture Research: Used as a nutrient and buffering agent in cell culture media and microbiological growth studies.
• Diagnostic Reagents: Employed in the formulation of diagnostic kits and enzymatic assay buffers.
• Nutraceutical & Cosmetic Ingredients: Incorporated into specialized dietary supplements and high-end cosmetic formulations for its skin-conditioning properties.
• Biochemical Standard: Serves as a reference standard in analytical chemistry and quality control laboratories.

Basic Information

Product Name	DL-Histidine Hydrochloride Dihydrate
CAS No.	31289-43-7
Molecular Formula	C6H9N3O2 • HCl • 2H2O
Molecular Weight	209.63 g/mol (Anhydrous basis)
Synonyms	DL-Histidine HCl Dihydrate; (±)-Histidine Hydrochloride Dihydrate; Histidine Hydrochloride (DL-Form) Dihydrate; 2-Amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride dihydrate; H-His-OH•HCl•2H2O; Racemic Histidine Hydrochloride Dihydrate; Histidine Monohydrochloride Dihydrate (DL)
EINECS	Contact for details

Quality Control

Our DL-Histidine Hydrochloride Dihydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as assay, optical rotation, heavy metals, and residual solvents. We support compliance with ICH guidelines and relevant pharmacopeial standards (USP/EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent clumping and decomposition. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥98.5%
Optical Rotation	-0.10° to +0.10° (c=1 in H2O)
Loss on Drying	14.0% - 17.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm
Related Substances (HPLC)	Total impurities ≤1.0%
Chloride Content (Titration)	16.5% - 17.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.