Description

n-ε-Boc-D-Lysine is a protected derivative of the non-natural D-isomer of the essential amino acid lysine, where the ε-amino group is specifically shielded with a tert-butoxycarbonyl (Boc) protecting group. This specific protection is critical for enabling selective peptide synthesis and modification in complex organic and medicinal chemistry workflows. It serves as a vital chiral building block for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require high-purity, enantiomerically pure intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based therapeutics, antibiotics, and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate D-lysine residues with orthogonal protection for the side chain, allowing for complex peptide architectures.
• Bioconjugation & Linker Chemistry: The protected amine group is utilized for creating stable amide linkages in antibody-drug conjugates (ADCs), diagnostic probes, and polymer-drug conjugates.
• Biochemical Research: Employed in enzymology studies and as a substrate analog to investigate enzyme mechanisms and inhibition.
• Material Science: Acts as a monomer or modifying agent for synthesizing functionalized polymers and biomaterials with specific chiral or bioactive properties.
• Process Development: Serves as a standard or reference compound in analytical method development and quality control for chiral amino acid analysis.

Basic Information

Product Name	n-ε-Boc-D-Lysine
CAS No.	31202-69-4
Molecular Formula	C11H22N2O4
Molecular Weight	246.31 g/mol
Synonyms	D-Lysine, N6-[(1,1-dimethylethoxy)carbonyl]-; N-ε-Boc-D-lysine; Boc-D-Lys-OH; (R)-2-Amino-6-((tert-butoxycarbonyl)amino)hexanoic acid; N6-Boc-D-lysine; D-Boc-Lys-OH; Boc-D-Lysine; tert-Butyloxycarbonyl-D-lysine
EINECS	Contact for details

Quality Control

Our n-ε-Boc-D-Lysine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet the high standards required for research and cGMP manufacturing. A Certificate of Analysis (COA) detailing specific results for chiral purity (HPLC), assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.