Description

(2S,4R)-4-Methylglutamic Acid is a high-purity, stereochemically defined non-proteinogenic amino acid derivative. This compound is a critical chiral building block and intermediate in advanced pharmaceutical synthesis and biochemical research. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutics and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drugs, enzyme inhibitors, and other bioactive compounds.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Proteomics & Peptide Chemistry: Incorporated into custom peptides to study structure-activity relationships (SAR) and protein folding.
• Neurology Research: Investigated for its potential interaction with glutamate receptors and transporters in neurological studies.
• Asymmetric Synthesis: Serves as a valuable chiral pool reagent for constructing complex molecules with defined stereocenters.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	(2S,4R)-4-Methylglutamic Acid
CAS No.	31137-74-3
Molecular Formula	C6H11NO4
Molecular Weight	161.16 g/mol
Synonyms	(2S,4R)-4-Methyl-L-glutamic Acid; (2S,4R)-4-Methylglutamate; 4-Methyl-DL-glutamic Acid (stereoisomer mixture); (2S,4R)-2-Amino-4-methylpentanedioic Acid; 4-Methylglutamic Acid; 4-MGA; 4-Me-Glu
EINECS	Contact for details

Quality Control

Our (2S,4R)-4-Methylglutamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (diastereomeric excess)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.