Description

L-3,5-Difluorophe is a fluorinated aromatic compound serving as a versatile chiral building block in advanced organic synthesis. Its value lies in the introduction of fluorine atoms and a specific stereocenter, which are critical for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of fluorinated active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Building block for developing new-generation herbicides and pesticides where fluorine substitution enhances efficacy and environmental profile.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands for asymmetric catalysis, enabling more efficient and selective chemical transformations.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Diagnostic Reagents: Potential intermediate for synthesizing fluorinated probes and markers used in imaging and bioanalytical applications.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for complex, high-value fluorinated compounds.

Basic Information

Item	Details
Product Name	L-3,5-Difluorophe
CAS No.	31105-91-6
Molecular Formula	C9H9F2NO2
Molecular Weight	201.17 g/mol
Synonyms	(S)-3,5-Difluorophenylalanine; L-3,5-Difluorophenylalanine; (S)-2-Amino-3-(3,5-difluorophenyl)propanoic acid; 3,5-Difluoro-L-phenylalanine; F2Phe(3,5); 3,5-Difluoro-DL-phenylalanine (related); 3,5-Difluoro Phe; 3,5-F2-Phe
EINECS	Contact for details

Quality Control

Our L-3,5-Difluorophe is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing specific results for identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.