Description

Fluphenazine N4'-Oxide is a key pharmaceutical intermediate and metabolite of the antipsychotic agent fluphenazine. This compound is of significant interest in analytical chemistry and pharmaceutical research for method development, impurity profiling, and metabolic studies. It serves as a critical reference standard for quality control laboratories and R&D departments within the global pharmaceutical and life sciences sectors.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of fluphenazine and its related substances in drug products and active pharmaceutical ingredients (APIs).
• Metabolite Studies: Essential for in-vitro and in-vivo metabolic pathway research to understand the pharmacokinetics and biotransformation of fluphenazine.
• Impurity Profiling: Acts as a specified impurity standard to ensure drug purity and compliance with stringent pharmacopeial guidelines (e.g., USP, EP, ICH Q3B).
• Analytical Method Development: Employed in the development and validation of HPLC, LC-MS, and other chromatographic methods for accurate analysis.
• Pharmacological Research: Utilized in preclinical studies to investigate the activity and stability of fluphenazine derivatives.
• Quality Control & Assurance: Critical for batch release testing in API and finished dosage form manufacturing to guarantee product safety and efficacy.

Basic Information

Product Name	Fluphenazine N4'-Oxide
CAS No.	30897-25-7
Molecular Formula	C22H26F3N3OS
Molecular Weight	437.52 g/mol
Synonyms	Fluphenazine N-Oxide; Fluphenazine Sulfoxide; 2-[4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazinyl]ethanol S-Oxide; 10-[3-[4-(2-Hydroxyethyl)piperazin-1-yl]propyl]-2-(trifluoromethyl)phenothiazine 5-Oxide; Fluphenazine S-Oxide; Flufenazin N-Oxid; Fluphenazine Sulfoxide Impurity
EINECS	Contact for details

Quality Control

Our Fluphenazine N4'-Oxide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances, to ensure it meets high-purity standards suitable for research and analytical use. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.