Description

4-Hydroxyalprazolam is a key pharmaceutical intermediate and metabolite of the benzodiazepine class. This compound is of significant importance for research and development in analytical chemistry and pharmacology, particularly for method development and metabolite studies. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism, pharmacokinetics (DMPK), and forensic analysis.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification and identification of alprazolam metabolites in bioanalytical studies.
• Metabolite Research: Critical for investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of alprazolam in preclinical and clinical research.
• Analytical Method Development: Used as a high-purity standard to develop and validate sensitive analytical methods, such as LC-MS/MS and HPLC, for forensic and clinical toxicology.
• Impurity Profiling: Employed in the quality control of active pharmaceutical ingredients (APIs) to identify and quantify related substances and degradation products.
• Diagnostic Kit Manufacturing: A vital component in the production of immunoassay kits and other diagnostic tools for therapeutic drug monitoring (TDM).

Basic Information

Product Name	4-Hydroxyalprazolam
CAS No.	30896-57-2
Molecular Formula	C17H13ClN4O
Molecular Weight	324.76 g/mol
Synonyms	α-Hydroxyalprazolam; 8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-ol; Alprazolam Metabolite; 4'-Hydroxyalprazolam; 1-Methyl-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepin-4-ol
EINECS	Contact for details

Quality Control

Our 4-Hydroxyalprazolam is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and reference standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles by validated methods (e.g., HPLC, NMR) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.