Description

Bradykinin Potentiator B is a specific, nonapeptide bradykinin potentiating factor originally isolated from the venom of the snake Bothrops jararaca. This compound is of significant interest in biochemical and pharmacological research due to its role in modulating the renin-angiotensin system and its interaction with angiotensin-converting enzyme (ACE). It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in cardiovascular research, peptide studies, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a reference standard and tool compound in studies investigating the renin-angiotensin-aldosterone system (RAAS) and blood pressure regulation.
• Pharmacological Studies: Employed in in vitro and in vivo assays to understand ACE inhibition mechanisms and the physiological effects of bradykinin potentiation.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the research pipeline for developing new antihypertensive and cardiovascular drugs.
• Peptide Chemistry: Used in academic and industrial laboratories for studying peptide structure-activity relationships (SAR) and synthesis methodologies.
• Enzyme Inhibition Assays: Acts as a specific inhibitor in assays designed to measure ACE activity, crucial for screening potential new inhibitors.
• Toxinology & Venom Research: Studied as a bioactive component of snake venom to understand its evolutionary role and potential therapeutic applications.

Basic Information

Product Name	Bradykinin Potentiator B
CAS No.	30892-86-5
Molecular Formula	C49H70N14O11
Molecular Weight	1031.2 g/mol
Synonyms	BPPb; Bradykinin-Potentiating Peptide B; Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro; Glp-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro; Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OH; Bothrops jararaca Bradykinin Potentiator B; Nonapeptide BPPb; ACE Inhibitor Peptide B
EINECS	Contact for details

Quality Control

Our Bradykinin Potentiator B is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is subjected to comprehensive analytical testing including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the results against our rigorous internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Biological Activity (ACE Inhibition Assay)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.