Description

2-Chloro-10-[2-(Dimethylamino)Ethyl]-5-Methyl-5H-Dibenz[B,F]Azepine is a high-purity, synthetically derived dibenzazepine derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of complex active pharmaceutical ingredients (APIs) with precise structural control. This compound is essential for research and development chemists and manufacturers in the pharmaceutical industry, particularly those focused on central nervous system (CNS) and psychotropic drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel tricyclic antidepressant and antipsychotic drug candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new dibenzazepine-based therapeutics.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex heterocyclic compounds in pilot plants and commercial production.

Basic Information

Product Name	2-Chloro-10-[2-(Dimethylamino)Ethyl]-5-Methyl-5H-Dibenz[B,F]Azepine
CAS No.	30490-63-2
Molecular Formula	C19H21ClN2
Molecular Weight	312.84 g/mol
Synonyms	2-Chloro-10-(2-dimethylaminoethyl)-5-methyldibenz[b,f]azepine; 2-Chloroimipramine; Desmethylclomipramine; Norclomipramine; NSC 169865; 5H-Dibenz[b,f]azepine, 2-chloro-10-[2-(dimethylamino)ethyl]-5-methyl-; 30490-63-2
EINECS	Contact for details

Quality Control

Our 2-Chloro-10-[2-(Dimethylamino)Ethyl]-5-Methyl-5H-Dibenz[B,F]Azepine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.