Description

5-Iodoisocytosine is a halogenated nucleobase derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a versatile and critical building block for the development of novel nucleoside analogs, antiviral agents, and other biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, agrochemical development, and the synthesis of modified oligonucleotides.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and the development of targeted therapeutic agents.
• Agrochemical Synthesis: Employed in the research and development of new pesticides and herbicides that target specific biological pathways.
• Bioconjugation & Probe Development: Useful for creating labeled probes or conjugates for biochemical assays and diagnostic applications due to the reactive iodine moiety.
• Oligonucleotide Modification: Serves as a modified base for incorporating specific functionalities into synthetic DNA or RNA strands.
• Academic & Industrial R&D: A valuable reagent for exploratory synthetic chemistry in both university laboratories and corporate R&D facilities.

Basic Information

Product Name	5-Iodoisocytosine
CAS No.	3993-79-1
Molecular Formula	C4H4IN3O
Molecular Weight	237.00 g/mol
Synonyms	5-Iodo-1H-pyrimidine-2,4-dione; 5-Iodo-2,4(1H,3H)-pyrimidinedione; 5-Iodoisocytosine; 5-Iodouracil (isomeric form); 2-Hydroxy-4-amino-5-iodopyrimidine; 4-Amino-5-iodo-2(1H)-pyrimidinone; 5-Iodo-4-aminouracil
EINECS	Contact for details

Quality Control

Our 5-Iodoisocytosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.