Description

H-(2S,4S)-γ-Hydroxy-Glu-Oh is a high-purity, stereochemically defined amino acid derivative. This compound is a critical chiral building block for the synthesis of complex bioactive molecules, offering precise control over stereochemistry in pharmaceutical development. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-fidelity intermediates for peptide synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a specialized, protected amino acid derivative in solid-phase and solution-phase peptide synthesis to introduce specific structural motifs.
• Protease Inhibitor Development: Serves as a core structural component in the design and synthesis of enzyme inhibitors targeting proteases.
• Biochemical Research: Employed as a standard or reagent in biochemical studies involving amino acid metabolism and enzyme-substrate interactions.
• Conjugation Chemistry: Utilized in bioconjugation strategies for linking peptides to other molecules, such as drugs, dyes, or polymers.
• Fine Chemical Synthesis: Acts as a building block for the preparation of complex natural product analogs and other specialty chemicals.

Basic Information

Product Name	H-(2S,4S)-γ-Hydroxy-Glu-Oh
CAS No.	3913-68-6
Molecular Formula	C5H9NO5
Molecular Weight	163.13 g/mol
Synonyms	(2S,4S)-4-Hydroxyglutamic Acid; L-threo-4-Hydroxyglutamic Acid; H-Glu(4-OH)-OH; γ-Hydroxy-L-glutamic Acid; (2S,4S)-2-Amino-4-hydroxyglutaric Acid; 4-Hydroxy-L-glutamate; 3913-68-6; γ-Hydroxyglutamic Acid
EINECS	223-476-7

Quality Control

Our H-(2S,4S)-γ-Hydroxy-Glu-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (2S,4S)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.