Description

(S)-5-Guanidino-2-(4-Nitrobenzamido)Pentanoic Acid CAS NO 3908-12-1 is a high-purity, non-natural amino acid derivative characterized by its chiral (S)-configuration and functional guanidino and nitrobenzamido groups. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the development of novel bioactive molecules. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on peptide-based drug discovery, enzyme inhibitor development, and proteomics research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel peptide-based therapeutics and enzyme inhibitors.
• Bioconjugation & Probe Development: Used in the design and synthesis of affinity probes, activity-based probes (ABPs), and bioconjugates for proteomics and chemical biology studies.
• Peptide Mimetic Research: Serves as a constrained or modified amino acid residue in the development of peptidomimetics with enhanced stability and biological activity.
• Chemical Biology Tool: Employed in the study of enzyme-substrate interactions, particularly for arginine-recognizing enzymes like trypsin-like proteases, due to its guanidino moiety.
• Agrochemical Research: Potential intermediate in the synthesis of specialized amino acid-based active ingredients.
• Academic & R&D: A valuable reagent for methodological development in asymmetric synthesis and for exploring new reaction pathways in organic chemistry.

Basic Information

Product Name	(S)-5-Guanidino-2-(4-Nitrobenzamido)Pentanoic Acid
CAS No.	3908-12-1
Molecular Formula	C13H17N5O5
Molecular Weight	323.31 g/mol
Synonyms	Nα-(4-Nitrobenzoyl)-L-arginine; L-Nα-(4-Nitrobenzoyl)arginine; (S)-2-[(4-Nitrobenzoyl)amino]-5-guanidinopentanoic acid; 4-Nitrohippuryl-L-arginine; Nα-4-Nitrobenzoyl-L-arginine; Nα-(p-Nitrobenzoyl)-L-arginine; p-Nitrohippuryl-L-arginine; Bz(NO2)-L-Arg-OH
EINECS	Contact for details

Quality Control

Our (S)-5-Guanidino-2-(4-Nitrobenzamido)Pentanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.