Description

Boc-Met-Osu CAS NO 3845-64-5 is a high-purity, protected amino acid derivative, specifically N-α-(tert-Butoxycarbonyl)-L-methionine N-hydroxysuccinimide ester. This compound is a critical reagent for the efficient and selective introduction of the Boc-protected methionine residue into peptide chains during solid-phase and solution-phase synthesis. Its primary value lies in enabling the controlled construction of complex peptides and proteins for research and development. This product is essential for pharmaceutical researchers, biochemists, and CROs engaged in peptide synthesis, proteomics, and the development of novel therapeutic agents.

Application

• Peptide Synthesis: A key building block for the incorporation of methionine in solid-phase peptide synthesis (SPPS) and solution-phase methodologies.
• Bioconjugation: Used to label proteins, antibodies, or other biomolecules with methionine-containing tags or probes via active ester chemistry.
• Pharmaceutical Intermediate: Serves as a crucial intermediate in the research and development of peptide-based drugs and diagnostic agents.
• Protecting Group Strategy: Facilitates orthogonal protection strategies in multi-step organic synthesis, where the Boc group can be selectively removed under mild acidic conditions.
• Biochemical Research: Employed in studies of protein structure-function relationships, enzyme substrates, and the synthesis of custom peptide libraries for screening.
• Material Science: Potential use in the synthesis of peptide-polymer conjugates or bio-inspired materials.

Basic Information

Product Name	Boc-Met-Osu
CAS No.	3845-64-5
Molecular Formula	C15H24N2O6S
Molecular Weight	360.43 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-L-methionine N-hydroxysuccinimide ester; Boc-L-methionine N-succinimidyl ester; Boc-Met-OSu; Boc-Met-ONSu; (S)-2-((tert-Butoxycarbonyl)amino)-4-(methylthio)butanoic acid 2,5-dioxopyrrolidin-1-yl ester; N-(tert-Butoxycarbonyl)-L-methionine succinimidyl ester; Boc-Met-Osu ester; Boc-Methionine-OSu
EINECS	223-350-6

Quality Control

Our Boc-Met-Osu is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. Each lot is analyzed via HPLC, NMR, and optical rotation to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles for the production of key intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-20.0° to -24.0° (c=1 in DMF)
Melting Point	108°C - 112°C
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.