Description

L-2-Trifluoromethylphenylalanine is a non-natural, fluorinated amino acid derivative of significant interest in advanced chemical synthesis. Its core value lies in the unique properties imparted by the trifluoromethyl group, which can dramatically enhance the metabolic stability, lipophilicity, and bioavailability of target molecules. This high-purity building block is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel peptide-based therapeutics, enzyme inhibitors, and bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and other enzyme-targeted drugs.
• Peptidomimetics & Drug Design: Used to incorporate fluorinated aromatic side chains into peptides, enhancing their stability against enzymatic degradation and improving membrane permeability.
• Agrochemical Research: Serves as a key intermediate in the development of advanced herbicides, pesticides, and plant growth regulators with improved efficacy and environmental profiles.
• Biochemical Tool Compound: Employed in academic and industrial research to study enzyme mechanisms, protein-ligand interactions, and metabolic pathways.
• Material Science: Potential monomer or additive for creating specialized polymers and coatings with unique surface properties.
• Diagnostic Agent Development: Used in the synthesis of radiolabeled probes or contrast agents for medical imaging techniques like PET (Positron Emission Tomography).

Basic Information

Product Name	L-2-Trifluoromethylphenylalanine
CAS No.	3832-73-3
Molecular Formula	C₁₀H₁₀F₃NO₂
Molecular Weight	233.19 g/mol
Synonyms	(S)-2-Amino-3-[2-(trifluoromethyl)phenyl]propanoic acid; L-α-Amino-2-(trifluoromethyl)benzenepropanoic acid; (S)-2-Trifluoromethylphenylalanine; L-2-(Trifluoromethyl)phenylalanine; Fmoc-L-2-TfmPhe-OH (when protected); Boc-L-2-TfmPhe-OH (when protected); 2-CF3-L-Phe; (S)-3-(2-(Trifluoromethyl)phenyl)alanine
EINECS	223-331-1

Quality Control

Our L-2-Trifluoromethylphenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets the highest standards of purity and chiral integrity, suitable for demanding research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity (by HPLC), enantiomeric excess, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Maximum Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.