Description

2-Chloro-5-Fluorophenol is a versatile halogenated phenol derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and fluoro substituents, makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Building block for manufacturing herbicides, fungicides, and pesticides, leveraging its bioactivity.
• Liquid Crystal & OLED Materials: Used in the development of electronic display components and organic light-emitting diodes due to its aromatic stability and substitution pattern.
• Polymer & Resin Modifier: Acts as a monomer or additive to impart specific chemical resistance or thermal properties to advanced polymers.
• Dye & Pigment Manufacturing: Intermediate for producing halogenated dyes and specialty colorants.
• Cross-Coupling Reactions: Valuable substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions for C-C and C-N bond formation.

Basic Information

Product Name	2-Chloro-5-Fluorophenol
CAS No.	3827-49-4
Molecular Formula	C6H4ClFO
Molecular Weight	146.55 g/mol
Synonyms	5-Fluoro-2-chlorophenol; 2-Chloro-5-fluorophenol; 2-Chloro-5-fluoro-1-hydroxybenzene; Phenol, 2-chloro-5-fluoro-; o-Chloro-p-fluorophenol; 1-Hydroxy-2-chloro-5-fluorobenzene; 2-Chloro-5-fluorophenol (principal name); 5-Fluoro-o-chlorophenol
EINECS	223-334-5

Quality Control

Our 2-Chloro-5-Fluorophenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	32 - 36 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.