Description

Benzenemethanol, A-Ethynyl-4-Fluoro- is a high-purity fluorinated aromatic building block featuring both a propargylic alcohol and a fluorine substituent. This unique bifunctional structure makes it a versatile intermediate for advanced organic synthesis, particularly in the development of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, especially in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the fluorine atom enhances bioavailability and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced materials.
• Click Chemistry Substrate: The terminal alkyne group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and polymer functionalization.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organometallic catalysts for asymmetric synthesis.
• Fluorine-18 Labeling Precursor: Potential synthon for radiopharmaceuticals in Positron Emission Tomography (PET) imaging.

Basic Information

Product Name	Benzenemethanol, A-Ethynyl-4-Fluoro-
CAS No.	3798-61-6
Molecular Formula	C9H7FO
Molecular Weight	150.15 g/mol
Synonyms	4-Fluoro-α-ethynylbenzyl Alcohol; 1-(4-Fluorophenyl)-2-propyn-1-ol; (4-Fluorophenyl)(prop-2-yn-1-yl)methanol; α-Ethynyl-4-fluorobenzyl Alcohol; 4-Fluoro-α-ethynylbenzenemethanol; 4-Fluoro-α-ethynylbenzylalcohol; 4-Fluoro-α-ethynyl-benzyl alcohol; 4-Fluoro-α-ethynyl-benzenemethanol
EINECS	Contact for details

Quality Control

Our Benzenemethanol, A-Ethynyl-4-Fluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.