Description

(S)-Phenprocoumon is the single enantiomer of the widely used anticoagulant phenprocoumon, offering a high-purity standard for advanced pharmaceutical research and development. This specific stereoisomer is critical for studying stereoselective metabolism, receptor binding, and for the development of more targeted therapeutic agents with potentially improved safety profiles. It is an essential reference standard and building block for researchers and manufacturers in the pharmaceutical and fine chemical sectors focusing on cardiovascular drug discovery and chiral synthesis.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, GC-MS) for quality control of racemic phenprocoumon APIs and formulations.
• Chiral Drug Research: Serves as a key intermediate or precursor in the research and development of enantiomerically pure anticoagulant therapies.
• Metabolic and Pharmacokinetic Studies: Enables detailed investigation into the stereoselective absorption, distribution, metabolism, and excretion (ADME) of coumarin anticoagulants.
• Biochemical Assay Development: Utilized in vitro studies to understand the specific interaction of the (S)-enantiomer with vitamin K epoxide reductase (VKOR) and other biological targets.
• Academic and Institutional Research: Provides a defined chemical entity for fundamental studies in medicinal chemistry, pharmacology, and toxicology.

Basic Information

Product Name	(S)-Phenprocoumon
CAS No.	3770-63-6
Molecular Formula	C18H16O3
Molecular Weight	280.32 g/mol
Synonyms	(S)-3-(1-Phenylpropyl)-4-hydroxycoumarin; (S)-Phenprocoumon; (S)-Marcoumar; (S)-Falithrom; (S)-4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one; L-Phenprocoumon; (S)-3-(α-Ethylbenzyl)-4-hydroxycoumarin; (S)-Phenprocoumone
EINECS	223-219-7

Quality Control

Our (S)-Phenprocoumon is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, to ensure it meets the stringent requirements for research and development applications. A Certificate of Analysis (COA) detailing identity, purity (HPLC), enantiomeric excess, and related substances is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.