Description

n-Biotinyl-4-Aminobenzoic Acid is a high-purity biochemical derivative that combines the essential vitamin biotin with a para-aminobenzoic acid (PABA) moiety. This compound is critical for research and development in life sciences, serving as a versatile building block for creating targeted biotinylated probes and conjugates. It is primarily utilized by pharmaceutical R&D teams, diagnostic kit manufacturers, and academic researchers focused on molecular biology, assay development, and advanced drug delivery systems.

Application

• Bioconjugation & Probe Synthesis: A key reagent for the site-specific biotinylation of proteins, peptides, antibodies, and other biomolecules to create detection probes.
• Diagnostic Assay Development: Used in the manufacturing of ELISA, lateral flow assays, and other immunoassays that rely on the strong streptavidin-biotin interaction for signal amplification.
• Affinity Chromatography: Functionalizes resins and matrices for the purification of biomolecules via biotin-streptavidin affinity capture.
• Cell Biology & Imaging: Enables the labeling and visualization of cell surface receptors and other targets in fluorescence microscopy and flow cytometry.
• Drug Delivery Research: Investigated as a component in targeted therapeutic conjugates, leveraging biotin receptors for enhanced cellular uptake.
• Chemical Biology Tools: Serves as a precursor for synthesizing more complex chemical probes used in activity-based protein profiling and other discovery platforms.

Basic Information

Product Name	n-Biotinyl-4-Aminobenzoic Acid
CAS No.	3672-04-6
Molecular Formula	C17H21N3O4S
Molecular Weight	363.43 g/mol
Synonyms	4-[(5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl)amino]benzoic Acid; Biotinyl-PABA; Biotin-4-amidobenzoic Acid; N-Biotinyl-p-aminobenzoic Acid; Vitamin H-PABA Conjugate; Biotin-PABA; N-(+)-Biotinyl-4-aminobenzoic Acid
EINECS	Contact for details

Quality Control

Our n-Biotinyl-4-Aminobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.