Description

Z-Gly-Met-Oh is a protected dipeptide building block, specifically the Z-protected derivative of glycyl-methionine. This compound is a critical intermediate in the synthesis of more complex peptides and peptidomimetics, offering controlled reactivity for sequential coupling strategies. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide chemistry, medicinal chemistry, and the development of active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, stepwise assembly of custom peptide sequences in research and development.
• Solution-Phase Peptide Synthesis: Used in traditional solution-phase methods for constructing specific peptide fragments or smaller peptides.
• Medicinal Chemistry & Drug Discovery: Serves as a building block for creating peptide-based drug candidates, enzyme inhibitors, and receptor ligands.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, protein folding, and metabolic pathways involving methionine.
• Production of Custom Peptides: Essential for contract manufacturing organizations (CMOs) and fine chemical suppliers producing tailored peptides for clients.
• Academic Research & Teaching: Used in university laboratories for training and advanced research in organic synthesis and peptide chemistry.

Basic Information

Product Name	Z-Gly-Met-Oh
CAS No.	3561-48-6
Molecular Formula	C16H22N2O5S
Molecular Weight	354.42 g/mol
Synonyms	N-Carbobenzoxy-glycyl-methionine; Z-Gly-Met-OH; Benzyloxycarbonyl-glycyl-methionine; Nα-Z-Glycyl-L-methionine; Cbz-Gly-Met-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylthio)butanoic acid (common mis-assignment check); Glycine, N-[(phenylmethoxy)carbonyl]-, (S)-2-((2-aminoacetyl)amino)-4-(methylthio)butanoate; CBZ-Gly-Met
EINECS	Contact for details

Quality Control

Our Z-Gly-Met-Oh is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.