Description

Z-Gly-Phe-Ala-OH is a protected tripeptide derivative, widely utilized as a key building block in solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers requiring high-purity intermediates to construct complex peptide sequences with precise control. It is particularly valuable for the pharmaceutical, biotechnology, and academic research sectors focused on developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of longer, biologically active peptide sequences for drug discovery and development.
• Biochemical Research: Used in academic and industrial laboratories to study peptide structure, function, and enzyme-substrate interactions.
• Peptide Library Synthesis: Employed in combinatorial chemistry to create diverse peptide libraries for high-throughput screening against therapeutic targets.
• Custom Peptide Production: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides for clients.
• Protease Substrate Analog: Can be used to design and synthesize inhibitors or substrates for proteolytic enzymes.

Basic Information

Product Name	Z-Gly-Phe-Ala-OH
CAS No.	3480-80-6
Molecular Formula	C22H25N3O6
Molecular Weight	427.45 g/mol
Synonyms	N-Carbobenzoxy-glycyl-L-phenylalanyl-L-alanine; Z-Gly-Phe-Ala; Z-Gly-L-Phe-L-Ala-OH; Benzyloxycarbonyl-glycyl-phenylalanyl-alanine; CBZ-Gly-Phe-Ala-OH; Nα-(Benzyloxycarbonyl)glycyl-L-phenylalanyl-L-alanine; (S)-2-((((Benzyloxy)carbonyl)glycyl)amino)-3-phenyl-N-((S)-1-carboxyethyl)propanamide
EINECS	Contact for details

Quality Control

Our Z-Gly-Phe-Ala-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral purity analysis to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-20° to -25° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.