Description

(+)-α-Dihydrotetrabenazine CAS NO 3466-75-9 is a high-purity, stereochemically defined derivative of tetrabenazine, a compound of significant interest in neurological research. This enantiomerically pure form is critical for studies requiring precise molecular interaction, particularly in the investigation of vesicular monoamine transporter 2 (VMAT2) function. It is an essential reference standard and key intermediate for pharmaceutical R&D teams, medicinal chemists, and analytical laboratories focused on developing and validating treatments for movement disorders and related central nervous system conditions.

Application

• Pharmaceutical Reference Standard: Used as a certified primary standard for the quantitative analysis and quality control of active pharmaceutical ingredients (APIs) and finished drug products targeting VMAT2.
• Medicinal Chemistry Research: Serves as a crucial building block and precursor in the synthesis of novel therapeutic agents for neurological disorders, including Huntington's disease and tardive dyskinesia.
• Pharmacological Studies: Employed in in vitro and in vivo studies to investigate the binding kinetics, metabolism, and pharmacokinetic profiles of VMAT2 inhibitors.
• Analytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, and GC-MS methods for the detection and quantification of tetrabenazine and its metabolites in biological matrices.
• Process Chemistry & Scale-up: Acts as a high-purity intermediate in the optimization and scaling of synthetic routes for the commercial manufacturing of deuterated or other modified tetrabenazine analogs.

Basic Information

Product Name	(+)-α-Dihydrotetrabenazine
CAS No.	3466-75-9
Molecular Formula	C19H27NO3
Molecular Weight	317.42 g/mol
Synonyms	(+)-α-Dihydrotetrabenazine; (2R,3R,11bR)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol; (3R,11bR)-Dihydrotetrabenazine; (+)-DTBZ; RO 4-1544-6; Dihydrotetrabenazine (enantiomer); Tetrabenazine metabolite
EINECS	Contact for details

Quality Control

Our (+)-α-Dihydrotetrabenazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity (by HPLC), and specific tests for residual solvents and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.