Description

Boc-Leu-Osu CAS NO 3392-09-4 is a highly reactive N-hydroxysuccinimide (NHS) ester derivative of Boc-protected L-leucine, serving as a crucial building block in peptide synthesis. This compound is specifically engineered for efficient and selective amide bond formation, enabling the controlled introduction of the leucine amino acid under mild conditions. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and the production of custom peptides and bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the efficient coupling of Boc-Leucine to growing peptide chains on resin.
• Solution-Phase Peptide Synthesis: Used for the preparation of peptide fragments and small peptides in solution.
• Bioconjugation: Facilitates the site-specific labeling of proteins, antibodies, or other biomolecules with leucine-containing tags or probes.
• Pharmaceutical Intermediates: Serves as a critical intermediate in the synthesis of therapeutic peptides and peptidomimetics.
• Research & Development: Employed in academic and industrial R&D for exploring new peptide-based drugs and biochemical tools.
• Production of Protected Amino Acid Derivatives: Used to create other customized, protected amino acid active esters for specialized synthesis.

Basic Information

Product Name	Boc-Leu-Osu
CAS No.	3392-09-4
Molecular Formula	C15H24N2O6
Molecular Weight	328.36 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-L-leucine N-hydroxysuccinimide ester; Boc-L-leucine N-succinimidyl ester; Boc-Leu-OSu; tert-Butyloxycarbonyl-L-leucine N-hydroxysuccinimide ester; N-(tert-Butoxycarbonyl)-L-leucine succinimidyl ester; N-Boc-L-leucine hydroxysuccinimide ester; (S)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanoic acid 2,5-dioxopyrrolidin-1-yl ester; Boc-Leu-ONSu
EINECS	Contact for details

Quality Control

Our Boc-Leu-Osu is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with each shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.