Description

Cyclo(Phe-Leu) CAS NO 3354-31-2 is a synthetic cyclic dipeptide, also known as a diketopiperazine (DKP), formed from the amino acids L-phenylalanine and L-leucine. This compound is valued for its structural rigidity and role as a key scaffold in medicinal chemistry and peptide research. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery, as a building block for more complex molecules, and in biochemical studies.

Application

• Pharmaceutical Intermediate: Serves as a core scaffold or building block in the synthesis of novel drug candidates and bioactive compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and as a conformationally constrained peptide mimic.
• Biochemical Tool Compound: Employed in enzymatic studies and as a reference standard in analytical method development.
• Peptide Synthesis: Acts as a protected dipeptide unit or a starting material for the preparation of more complex cyclic and linear peptides.
• Cosmetic & Personal Care Actives: Investigated for potential use in anti-aging or skin-conditioning formulations due to its peptide nature.
• Academic & Industrial R&D: A fundamental reagent for exploring diketopiperazine chemistry and its diverse applications.

Basic Information

Product Name	Cyclo(Phe-Leu)
CAS No.	3354-31-2
Molecular Formula	C15H20N2O2
Molecular Weight	260.33 g/mol
Synonyms	Cyclo(L-phenylalanyl-L-leucyl); Cyclo(L-Phe-L-Leu); 3-Benzyl-6-isobutyl-2,5-piperazinedione; 3-Benzyl-6-isobutylpiperazine-2,5-dione; L-Phenylalanyl-L-leucine anhydride; DKPs; Diketopiperazine (Phe-Leu); 2,5-Diketopiperazine derivative; (3S,6S)-3-Benzyl-6-isobutylpiperazine-2,5-dione
EINECS	Contact for details

Quality Control

Our Cyclo(Phe-Leu) is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.