Description

Isoleucine, L-, [1-14C] CAS NO 3343-46-2 is a carbon-14 radiolabeled form of the essential branched-chain amino acid L-Isoleucine, specifically labeled at the first carbon position. This compound is a critical tool for metabolic pathway tracing, protein turnover studies, and pharmacokinetic research, offering unparalleled precision in tracking biochemical processes. It is primarily utilized by research scientists and quality control specialists in the pharmaceutical, biotechnology, and life science sectors for advanced analytical and investigative applications.

Application

• Metabolic Pathway Tracing: Used to study the metabolism and fate of isoleucine in biological systems, including plants, animals, and microorganisms.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the disposition of new drug candidates or their metabolites.
• Protein Synthesis and Turnover Research: Employed to measure rates of protein synthesis, degradation, and turnover in cell culture and in vivo models.
• Biochemical Assay Development: Serves as a labeled standard or tracer in the development and validation of sensitive analytical methods like LC-MS/MS.
• Nutritional and Clinical Research: Investigates isoleucine utilization, requirements, and its role in conditions like muscle wasting, liver disease, and metabolic disorders.
• Quality Control Reference Standard: Acts as an internal standard for the quantification of isoleucine in complex matrices within pharmaceutical or nutritional supplement quality control labs.

Basic Information

Product Name	Isoleucine, L-, [1-14C]
CAS No.	3343-46-2
Molecular Formula	C6H1314CNO2
Molecular Weight	Contact for details
Synonyms	L-Isoleucine-1-14C; (2S,3S)-2-Amino-3-methylpentanoic acid-1-14C; (2S,3S)-2-Azaniumyl-3-methylpentanoate-1-14C; ILE-1-14C; L-ILE-1-14C; Carbon-14 Labeled L-Isoleucine; Radiolabeled L-Isoleucine
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled L-Isoleucine is manufactured and analyzed under strict quality systems to ensure high chemical, radiochemical, and enantiomeric purity. Production adheres to cGMP principles where applicable. Comprehensive analytical testing, including HPLC, radio-HPLC, and specific activity determination, is performed. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and radiochemical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the primary container in a secondary sealed, light-resistant container in a cool, dry place. Handle and dispose of in accordance with all applicable radiation safety regulations.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98% (Chemical Purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	Contact for details (mCi/mmol)
Enantiomeric Purity (Chiral HPLC)	≥ 99% L-Isomer
Solubility	Soluble in water, dilute acid, or alkali

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.