Description

(S)-9,10-Didehydro-n-(1-Hydroxyethyl)-6-Methylergoline-8Beta-Carboxamide is a high-purity ergoline alkaloid derivative, a key chiral intermediate in advanced pharmaceutical synthesis. This compound matters for its critical role in the development and production of specialized active pharmaceutical ingredients (APIs) targeting neurological and cardiovascular systems. Pharmaceutical manufacturers and advanced research institutions need it for the synthesis of complex therapeutic agents, where its specific stereochemistry and structural integrity are paramount for efficacy and regulatory approval.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of complex ergot alkaloid-derived APIs.
• Neurological Research: Used in preclinical studies and development of compounds targeting serotonin and dopamine receptor pathways.
• Cardiovascular Drug Development: Serves as a precursor in the research of vasoactive and anti-migraine medications.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical labs.
• Process Chemistry & Scale-Up: Utilized in route scouting, optimization, and pilot-scale manufacturing of specialty pharmaceuticals.
• Asymmetric Synthesis: Leveraged for its defined stereocenter in the synthesis of other chiral molecules requiring high enantiomeric purity.

Basic Information

Product Name	(S)-9,10-Didehydro-n-(1-Hydroxyethyl)-6-Methylergoline-8Beta-Carboxamide
CAS No.	3343-15-5
Molecular Formula	C19H23N3O2
Molecular Weight	325.41 g/mol
Synonyms	Lisuride Impurity; Lisuride Related Compound A; (8β)-N-[(1S)-1-Hydroxyethyl]-9,10-didehydro-6-methylergoline-8-carboxamide; (S)-Lisuride EP Impurity A; Cabergoline Impurity; Pergolide Intermediate; Ergoline-8β-carboxamide derivative; U-32,089E
EINECS	Contact for details

Quality Control

Our (S)-9,10-Didehydro-n-(1-Hydroxyethyl)-6-Methylergoline-8Beta-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and related substance analysis by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediates and reference standards. Certificates of Analysis (COA) with full traceability are provided, and production can be aligned with cGMP guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.