Description

H-Ala-Nle-Oh CAS NO 3303-37-5 is a high-purity, synthetic dipeptide building block consisting of alanine and norleucine. This compound is a critical intermediate in the synthesis of complex peptides and peptidomimetics, offering precise structural control for research and development. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic institutions focused on drug discovery and biochemical studies.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase and solution-phase synthesis of therapeutic peptides and peptide hormones.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of novel peptidomimetic drug candidates.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and proteomics research to understand biological pathways.
• Cosmetic Peptide Synthesis: Incorporated into the development of bioactive peptides for advanced skincare and cosmetic formulations.
• Reference Standard: Employed as a chromatographic reference standard for quality control and analytical method development in peptide manufacturing.

Basic Information

Product Name	H-Ala-Nle-Oh
CAS No.	3303-37-5
Molecular Formula	C9H18N2O3
Molecular Weight	202.25 g/mol
Synonyms	L-Alanyl-L-norleucine; H-Ala-Nle-OH; Ala-Nle; L-Ala-L-Nle; Norleucylalanine; 2-[(2-Aminopropanoyl)amino]hexanoic acid; N-(1-Carboxyethyl)norleucine; (S)-2-((S)-2-Aminopropanamido)hexanoic acid
EINECS	Contact for details

Quality Control

Our H-Ala-Nle-Oh is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via mass spectrometry and IR spectroscopy. Certificates of Analysis (COA) with detailed chromatograms are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.