Description

4-(Trifluoromethyl)Benzylamine is a versatile aromatic amine building block characterized by a reactive primary amine group and a highly electron-withdrawing trifluoromethyl substituent. This unique structure makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules, significantly enhancing their pharmaceutical and agrochemical profiles. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the CF3 group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for electron-transport materials and alignment agents in display technologies.
• Polymer & Resin Modifier: Incorporated into epoxy hardeners and polyamide resins to enhance chemical resistance and thermal stability.
• Organic Synthesis Reagent: A valuable starting material for amide coupling, reductive amination, and the preparation of Schiff bases in fine chemical synthesis.
• Fluorinated Dye & Pigment Intermediate: Used to create specialty dyes and pigments with improved lightfastness and solubility properties.

Basic Information

Product Name	4-(Trifluoromethyl)Benzylamine
CAS No.	3300-51-4
Molecular Formula	C8H8F3N
Molecular Weight	175.15 g/mol
Synonyms	α-(Trifluoromethyl)benzylamine; (4-Trifluoromethylphenyl)methanamine; 4-(Trifluoromethyl)benzenemethanamine; p-(Trifluoromethyl)benzylamine; 4-(Trifluoromethyl)benzylamine; 1-[4-(Trifluoromethyl)phenyl]methanamine; 4-CF3-Benzylamine; 4-Trifluoromethylbenzylamine
EINECS	221-975-8

Quality Control

Our 4-(Trifluoromethyl)Benzylamine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC/HPLC for purity and identity confirmation, to ensure it meets the stringent requirements of our global clientele. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and physical properties.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent absorption of atmospheric moisture and CO2, which can lead to degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.