Description

Proline, 4-Amino- (7Ci,8Ci,9Ci) CAS NO 3285-76-5 is a specialized, non-proteinogenic amino acid derivative of proline, featuring an amino group at the 4-position of the pyrrolidine ring. This structural modification makes it a valuable chiral building block and intermediate for the synthesis of complex bioactive molecules. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for applications in drug discovery, peptide mimetics, and catalyst development. Our supply ensures high purity and batch-to-batch consistency critical for sensitive synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptidomimetics & Drug Discovery: Used to construct constrained peptide analogs and scaffolds that mimic natural peptide structures, enhancing metabolic stability and bioavailability in candidate drugs.
• Agrochemical Synthesis: Acts as a building block for developing novel herbicides, fungicides, and plant growth regulators with specific chiral activity.
• Catalyst & Ligand Development: Employed in the synthesis of chiral catalysts and ligands for asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development for amino acid analysis.
• Fine Chemical Synthesis: A versatile intermediate for custom synthesis projects requiring a functionalized proline derivative.

Basic Information

Product Name	Proline, 4-Amino- (7Ci,8Ci,9Ci) CAS NO 3285-76-5
CAS No.	3285-76-5
Molecular Formula	C5H10N2O2
Molecular Weight	130.15 g/mol
Synonyms	4-Aminoproline; cis-4-Aminoproline; (2S,4S)-4-Aminopyrrolidine-2-carboxylic acid; 4-Amino-D-proline; L-4-Aminoproline; 4-Amino-L-proline; 4-Aminopyrrolidine-2-carboxylic acid; 4-Amino-2-carboxypyrrolidine
EINECS	Contact for details

Quality Control

Every batch of 4-Aminoproline is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and synthesis. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available for all shipments. Our quality protocols are designed to support compliance in cGMP and ISO environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using a desiccant in the storage area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.