Description

n-Phthaloylglutamic Acid is a high-purity, versatile chemical intermediate derived from glutamic acid and phthalic anhydride. This compound is valued for its role as a key building block in the synthesis of complex organic molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by research institutions and industrial manufacturers engaged in developing active pharmaceutical ingredients (APIs), peptide synthesis, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of various active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used as a protected glutamic acid derivative in solid-phase and solution-phase peptide chemistry.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, dyes, and advanced material precursors.
• Biochemical Research: Utilized in proteomics and enzymology studies as a substrate or inhibitor analog.
• Academic & R&D: A standard reagent in university and corporate research laboratories for organic synthesis projects.

Basic Information

Product Name	n-Phthaloylglutamic Acid
CAS No.	3227-01-8
Molecular Formula	C13H11NO6
Molecular Weight	277.23 g/mol
Synonyms	N-Phthaloyl-L-glutamic Acid; (S)-2-(1,3-Dioxoisoindolin-2-yl)pentanedioic Acid; L-Glutamic Acid N-Phthaloyl Derivative; Phthaloylglutamic Acid; PGA; 2-Phthalimidoglutaric Acid; N-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-L-glutamic Acid
EINECS	221-759-2

Quality Control

Our n-Phthaloylglutamic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-30.0° to -35.0° (c=1 in DMF)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.