Description

3,4-Dehydroproline is a non-proteinogenic amino acid derivative characterized by a double bond within its proline ring structure. This unique structural feature makes it a valuable synthetic building block and a key intermediate in the preparation of more complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide chemistry, medicinal chemistry, and biochemical research. The compound is supplied with a high level of purity to meet the stringent requirements of advanced scientific applications.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel peptide-based drugs and protease inhibitors.
• Medicinal Chemistry Research: Used to introduce conformational constraints into peptide analogs, studying structure-activity relationships (SAR).
• Biochemical Probe Development: Acts as a precursor for labeled compounds used in metabolic pathway studies and enzyme mechanism investigations.
• Peptide Synthesis: Employed in solid-phase and solution-phase peptide synthesis to incorporate dehydroamino acid residues.
• Academic & Industrial R&D: Utilized in basic research exploring amino acid chemistry, protein folding, and biomimetic materials.

Basic Information

Product Name	3,4-Dehydroproline
CAS No.	3220-74-4
Molecular Formula	C5H7NO2
Molecular Weight	113.11 g/mol
Synonyms	3,4-Didehydroproline; (R)-3,4-Didehydroproline; δ3,4-Proline; 3,4-Dehydro-L-proline; 2-Pyrroline-2-carboxylic acid; 1-Azabicyclo[3.1.0]hexane-2-carboxylic acid
EINECS	221-746-6

Quality Control

Our 3,4-Dehydroproline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for identity confirmation, to ensure it meets high-purity research-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for that batch. We are committed to consistent quality and supply reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.