Description

Z-Asp(Ome)-Oh CAS NO 3160-47-2 is a protected aspartic acid derivative, specifically the Z-protected methyl ester of aspartic acid. This compound is a crucial building block in peptide synthesis, offering selective protection for the side-chain carboxylic acid group, which is essential for the controlled construction of complex peptide sequences. It is primarily used by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, APIs, and biochemical tools where precise molecular assembly is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of aspartic acid residues into peptide chains.
• Solution-Phase Peptide Chemistry: Used in classical peptide coupling strategies for research-scale and industrial-scale production.
• Pharmaceutical Intermediate: Serves as a critical raw material in the synthesis of peptide-based Active Pharmaceutical Ingredients (APIs).
• Bioconjugation and Labeling: The protected carboxylic acid group allows for selective modification and attachment of labels or other functional molecules.
• Biochemical Research: Employed in studying enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR).
• Production of Aspartame Analogs: Acts as a precursor in the synthesis of specialized sweeteners and flavor enhancers.

Basic Information

Product Name	Z-Asp(Ome)-Oh
CAS No.	3160-47-2
Molecular Formula	C13H17NO6
Molecular Weight	283.28 g/mol
Synonyms	N-Carbobenzoxy-L-aspartic acid 4-methyl ester; N-Cbz-L-aspartic acid 4-methyl ester; Z-L-Aspartic acid 4-methyl ester; (2S)-2-[[(Benzyloxy)carbonyl]amino]butanedioic acid 4-methyl ester; Z-Asp-OMe; Cbz-Asp-OMe; Nα-Cbz-L-aspartic acid β-methyl ester; Benzyl N-[(1S)-3-methoxy-1,3-dioxopropyl]carbamate
EINECS	221-607-7

Quality Control

Our Z-Asp(Ome)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and cGMP-grade requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.