Description

4-Chloro-2-(trichloromethyl)quinazoline is a versatile halogenated quinazoline derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both chloro and trichloromethyl substituents, makes it a valuable building block for constructing complex heterocyclic systems and active pharmaceutical ingredients (APIs). This high-purity compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various quinazoline-based drug candidates, including kinase inhibitors and other therapeutic agents.
• Agrochemical Synthesis: Used as a building block for developing novel herbicides, fungicides, and pesticides with specific modes of action.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of advanced polymers and organic electronic materials.
• Dye and Pigment Manufacturing: Intermediate for creating specialized heterocyclic dyes and colorants with enhanced properties.
• Chemical Biology Probes: Utilized in medicinal chemistry to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	4-Chloro-2-(trichloromethyl)quinazoline
CAS No.	3137-63-1
Molecular Formula	C9H4Cl4N2
Molecular Weight	282.95 g/mol
Synonyms	2-(Trichloromethyl)-4-chloroquinazoline; 4-Chloro-2-trichloromethylquinazoline; Quinazoline, 4-chloro-2-(trichloromethyl)-; 4-Chloro-2-(trichloromethyl)benzo[d]pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(trichloromethyl)quinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports your regulatory needs for research, development, and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly closed and stored in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.