Description

n-Methyl-L-Leucine is a non-proteinogenic amino acid derivative where a methyl group is attached to the nitrogen of the L-leucine backbone. This structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis. It is particularly significant for the research and development of peptide-based pharmaceuticals and bioactive compounds. Key industries that utilize this specialty chemical include pharmaceutical R&D, biotechnology, and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel peptide drugs and protease inhibitors.
• Biochemical Research: Used in studies of enzyme mechanisms, metabolic pathways, and as a non-standard amino acid in peptide science.
• Peptide Modification: Incorporated into custom peptides to alter their stability, bioavailability, and biological activity for drug discovery.
• Fine Chemical Synthesis: Acts as a building block for complex organic molecules, including natural product analogs and specialty agrochemicals.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Detail
Product Name	n-Methyl-L-Leucine
CAS No.	3060-46-6
Molecular Formula	C7H15NO2
Molecular Weight	145.20 g/mol
Synonyms	(S)-2-Amino-4-methylpentanoic acid N-methyl derivative; L-Leucine, N-methyl-; N-Methylleucine; 2-Amino-4-methyl-N-methylpentanoic acid; (2S)-2-(Methylamino)-4-methylpentanoic acid; Methylleucine; N-Methyl-L-2-amino-4-methylvaleric acid
EINECS	221-296-6

Quality Control

Our n-Methyl-L-Leucine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) documenting identity, purity, and specific tests are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Specific range provided on COA
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.