Description

3-Methylproline is a non-proteinogenic proline derivative, a chiral building block of significant interest in advanced organic synthesis and pharmaceutical research. Its constrained pyrrolidine ring structure makes it a valuable scaffold for designing peptidomimetics and modulating the conformational properties of bioactive molecules. This compound is particularly sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in drug discovery and the synthesis of complex natural products.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and cardiovascular drug research.
• Peptidomimetic Design: Used to construct conformationally restricted peptide analogs to enhance metabolic stability, bioavailability, and receptor selectivity.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective synthesis.
• Agrochemical Research: Employed in the development of novel herbicides and plant growth regulators with specific stereochemical requirements.
• Biochemical Research: Used as a probe or standard in studies of proline metabolism, collagen biosynthesis, and enzyme inhibition.
• Fine Chemical Synthesis: A versatile building block for the preparation of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	3-Methylproline
CAS No.	3005-84-3
Molecular Formula	C6H11NO2
Molecular Weight	129.16 g/mol
Synonyms	(2S,3S)-3-Methylpyrrolidine-2-carboxylic acid; (3S)-3-Methyl-L-proline; 3-Methyl-L-proline; L-3-Methylproline; 3-Methylproline; 3-Methyl-2-pyrrolidinecarboxylic acid; (S,S)-3-Methylproline; 3-Methyl-dl-proline
EINECS	221-108-5

Quality Control

Our 3-Methylproline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, enantiomeric excess, and impurity profile. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.