Description

2-Nitro-4-Fluorophenol is a versatile fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring both nitro and fluoro substituents on the phenol ring, makes it a critical building block for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic scaffolds.
• Agrochemical Synthesis: Used in the development of novel herbicides, pesticides, and fungicides, where the fluorine atom enhances biological activity and stability.
• Dye and Pigment Manufacturing: Serves as a starting material for producing specialized azo dyes and colorants.
• Liquid Crystal & Electronic Materials: A valuable monomer or intermediate in the production of advanced materials for display technologies.
• Organic Synthesis & Research: Employed in academic and industrial R&D for Suzuki coupling, nucleophilic aromatic substitution, and other cross-coupling reactions.
• Polymer Modification: Can be used to introduce functional groups into polymer chains to alter physical or chemical properties.

Basic Information

Product Name	2-Nitro-4-Fluorophenol
CAS No.	394-33-2
Molecular Formula	C6H4FNO3
Molecular Weight	157.10 g/mol
Synonyms	4-Fluoro-2-nitrophenol; 2-Nitro-4-fluorophenol; 4-Fluoro-2-nitro-1-hydroxybenzene; 1-Hydroxy-4-fluoro-2-nitrobenzene; Phenol, 4-fluoro-2-nitro-; 2-Nitro-4-fluorophenol; 4-Fluoro-2-nitrophenol; NSC 403841
EINECS	206-900-2

Quality Control

Our 2-Nitro-4-Fluorophenol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide full traceability and a Certificate of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	62 - 66 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.