Description

2-Amino-5-Fluorobenzotrifluoride is a high-value fluorinated aromatic amine building block, essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals. Its unique trifluoromethyl and fluorine substituents impart desirable properties such as metabolic stability and lipophilicity to target molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Dye & Pigment Intermediate: Employed in the production of specialized fluorinated dyes and pigments with unique color fastness and spectral properties.
• Polymer Modification: Acts as a monomer or modifier to introduce fluorine-containing side chains into polymers, improving their chemical resistance and surface properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) for constructing complex biaryl amines.

Basic Information

Product Name	2-Amino-5-Fluorobenzotrifluoride
CAS No.	393-39-5
Molecular Formula	C7H5F4N
Molecular Weight	179.12 g/mol
Synonyms	5-Fluoro-2-(trifluoromethyl)aniline; 2-Amino-α,α,α,5-tetrafluorotoluene; 2-Trifluoromethyl-5-fluoroaniline; 5-Fluoro-α,α,α-trifluoro-o-toluidine; 2-(Trifluoromethyl)-5-fluoroaniline; 5-Fluoro-2-trifluoromethylaniline; 2-Amino-5-fluorobenzylidene trifluoride; Benzenamine, 5-fluoro-2-(trifluoromethyl)-
EINECS	206-889-5

Quality Control

Our 2-Amino-5-Fluorobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.