Description

4-Bromo-3-(Trifluoromethyl)Aniline is a high-value halogenated aniline derivative, distinguished by its bromine and trifluoromethyl substituents which confer unique electronic and steric properties. This compound is a critical building block in advanced organic synthesis, enabling the development of complex molecules with tailored functionality. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for applications in drug discovery, crop protection, and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers.
• Dye and Pigment Intermediate: Acts as a building block for synthesizing complex dyes and functional pigments.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.

Basic Information

Product Name	4-Bromo-3-(Trifluoromethyl)Aniline
CAS No.	393-36-2
Molecular Formula	C7H5BrF3N
Molecular Weight	240.02 g/mol
Synonyms	3-(Trifluoromethyl)-4-bromoaniline; 4-Bromo-α,α,α-trifluoro-m-toluidine; 4-Bromo-3-trifluoromethylaniline; 4-Bromo-α,α,α-trifluoro-3-methylaniline; 1-Amino-4-bromo-3-(trifluoromethyl)benzene; 4-Bromo-3-(trifluoromethyl)benzenamine; 3-Trifluoromethyl-4-bromoaniline
EINECS	206-889-9

Quality Control

Our 4-Bromo-3-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store this material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Light yellow to beige crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.