Description

4-(Trifluoromethyl)-1H-Indole-2,3-Dione is a versatile and high-value trifluoromethylated heterocyclic building block. This compound is crucial for introducing the metabolically stable and lipophilic trifluoromethyl group into complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and environmental stability.
• Material Science: Building block for advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Fluorinated Dye & Pigment Synthesis: Serves as a core structure for creating specialized fluorinated colorants with unique properties.
• Academic & Contract Research: Essential reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Ligand & Catalyst Development: Used to construct novel chelating agents and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	4-(Trifluoromethyl)-1H-Indole-2,3-Dione
CAS No.	386-73-2
Molecular Formula	C9H4F3NO2
Molecular Weight	215.13 g/mol
Synonyms	4-(Trifluoromethyl)isatin; 4-Trifluoromethylisatin; 4-Trifluoromethyl-1H-indole-2,3-dione; 4-CF3-isatin; Isatin, 4-(trifluoromethyl)-; 2,3-Dihydro-2,3-dioxo-4-(trifluoromethyl)indole; 4-(Trifluoromethyl)-2,3-indolinedione
EINECS	206-870-7

Quality Control

Our 4-(Trifluoromethyl)-1H-Indole-2,3-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with every shipment, and custom purity grades (e.g., >98%, >99%) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.