Description

2-Nitro-3-(Trifluoromethyl)Phenol is a versatile fluorinated phenolic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring both nitro and trifluoromethyl substituents, makes it a critical building block for creating complex molecules with tailored properties. This compound is essential for research and development chemists and process engineers in the agrochemical and pharmaceutical industries seeking to introduce fluorine atoms and specific functional groups into target molecules.

Application

• Agrochemical Intermediate: Serves as a key precursor in the synthesis of novel herbicides, pesticides, and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Pharmaceutical Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for constructing fluorinated aromatic cores that can improve metabolic stability and bioavailability.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing specialized dyes, pigments, and optical brighteners, leveraging its nitro and phenolic functionalities.
• Liquid Crystal & Electronic Materials: Employed in the synthesis of advanced materials, such as liquid crystal compounds and organic semiconductors, where fluorine substitution is crucial for performance.
• Cross-Coupling Reactions: Functions as a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for creating complex biaryl structures.
• Chemical Research & Development: Utilized as a standard or building block in academic and industrial R&D for exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	2-Nitro-3-(Trifluoromethyl)Phenol
CAS No.	386-72-1
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	3-(Trifluoromethyl)-2-nitrophenol; 2-Nitro-α,α,α-trifluoro-m-cresol; 2-Nitro-3-trifluoromethylphenol; 2-Nitro-3-(trifluoromethyl)benzenol; Phenol, 2-nitro-3-(trifluoromethyl)-; NSC 404080; m-Cresol, 2-nitro-3-trifluoromethyl-
EINECS	206-861-5

Quality Control

Our 2-Nitro-3-(Trifluoromethyl)Phenol is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.