Description

Ethyl Trifluoroacetate is a versatile fluorinated organic ester, widely recognized for its utility as a powerful acylating and trifluoroacetylating agent in synthetic chemistry. Its high reactivity and the stability of the trifluoroacetyl group make it a critical reagent for introducing fluorine-containing moieties into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise fluorination is required to modify compound properties such as metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the production of fluorinated drugs and peptides.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, pesticides, and fungicides that benefit from fluorine's unique biological activity.
• Protecting Group Reagent: Employed in organic synthesis to introduce the trifluoroacetyl (TFA) protecting group for amines and alcohols, which can be removed under mild conditions.
• Polymer & Material Science: Serves as a monomer or modifier in the production of specialty fluoropolymers and high-performance materials.
• Analytical Chemistry: Utilized as a derivatization agent in gas chromatography and mass spectrometry to enhance the detection of analytes.
• Fine Chemical Production: Acylating agent in the synthesis of complex flavors, fragrances, and other high-value fine chemicals.

Basic Information

Product Name	Ethyl Trifluoroacetate
CAS No.	383-63-1
Molecular Formula	C4H5F3O2
Molecular Weight	142.08 g/mol
Synonyms	Trifluoroacetic Acid Ethyl Ester; Ethyl Perfluoroacetate; TFA Ethyl Ester; Ethyl 2,2,2-Trifluoroacetate; ETA; Ethyl Trifluoroethanoate; 2,2,2-Trifluoroacetic Acid Ethyl Ester; NSC 4631
EINECS	206-851-2

Quality Control

Our Ethyl Trifluoroacetate is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide full traceability and detailed Certificates of Analysis (COA) upon request, confirming compliance with relevant industry standards for use in research and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases, strong oxidizing agents, and strong reducing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for extended shelf life.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.0%
Water Content (KF)	≤ 0.1%
Refractive Index (n20D)	1.306 - 1.310
Density (20°C)	1.195 - 1.205 g/mL
Boiling Point	60 - 62°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.